The Barr body is a looped X chromosome formed by telomere association.
收藏PubMed Central1991-07-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC52048/
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We examined Barr bodies formed by isodicentric human X chromosomes in cultured human cells and in mouse-human hybrids using confocal microscopy and DNA probes for centromere and subtelomere regions. At interphase, the two ends of these chromosomes are only a micron apart, indicating that these inactive X chromosomes are in a nonlinear configuration. Additional studies of normal X chromosomes reveal the same telomere association for the inactive X but not for the active X chromosome. This nonlinear configuration is maintained during mitosis and in a murine environment. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-07-15
