Additional file 2: of The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia

Table S1. List of siRNA targets resulting in positive differential circularity. Primary microglia were transfected with a pool of siRNA oligonucleotides against each gene and tested for their effect on CM-induced microglia ramification. The result was expressed as differential circularity. siRNAs that caused positive differential circularity values were selected and sorted by their fold discovery rate (FDR), which represents an adjusted P value. Statistically significant genes were marked in bold. Genes that were annotated by the Parkinsonâ s UK Gene Ontology Project [22] are marked in the PD gene column. Genes that were listed in the PD map tool of the University of Luxembourg ( http://pdmap.uni.lu/minerva/ ) are marked in the PD map column [23]. Genes overlapping with differential transcriptome expression data from post mortem tissue of the substantia nigra [24] published on the PD map webpage ( http://pdmap.uni.lu/minerva/ ) are marked in the last column. *Positive hits that were selected for validation. (XLSX 55Â kb)