Different hot spot mutations in the TP53 genes exerts different biology and outcome

We report that R273 mutation in the TP53 gene in Colorectal cancer promotes transcriptional signature affecting cytoskeleton dynamics and increasing cell migration. This signature is not a general transcriptional output of mutantp53 as other known hot spot such as R175H mutation could not exerts this signature. Overall design: Examination of two different hot spot mutations in the TP53 gene compared to p53 null cells