Impact of Circadian-Microbiome Interaction on the Gut-Pancreas Axis in Aging. Homo sapiens

This study will examine the role of abnormal eating time (a common lifestyle factor that affects circadian rhythm) in accelerating aging by modulating intestinal barrier damage, microbiota dysbiosis, gut leakiness, and pancreas damage. Microbial signaling networks and their interaction with host biological rhythms as targetable mechanisms involved in aging will be studied. Findings from this study will identify intervenable mechanisms to prevent organ damage by age.