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Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1

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Protein Data Bank Japan2024-03-27 更新2026-03-21 收录
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Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 Descriptor: (9cis)-retinoic acid, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, Bile acid receptor, ... Authors: Wang, N, Liu, J. Deposit date: 2018-06-25 Release date: 2018-10-10 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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2018-06-25
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