Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions

Disclosed
herein is a dehydrosilylative difluoroamidation of α-Csp3–H of tetrahydroisoquinolines with α,α-difluoro-α-TMS-acetamides.
The process, which occurs at ambient temperature in the absence of
any transition metals, provides direct access to a broad range of
α,α-difluoroacetamide-substituted tertiary amine derivatives
in high yields. Moreover, the method was successfully applied in the
Csp3–H-directed difluorophosphorylation and difluorocarboxylation
under the same conditions.