Time resolved observation of substrate and drug binding with 1000 Hz X-ray pulses with 10-90 us duration

As a group which has pioneered work at Free Electron Lasers for time resolved structural work on proteins we are interested to understand biologic processes
from the structural point of view like Enzymology and Light driven reactions like photosynthesis or light triggered reactions of eg cytochrome c oxidase. From
health science we try understanding the binding of drugs to fight cancer and the mechanism of Nendo U one of the proteins which gets expressed during Covid
infection, this virus specific protein cuts off the poly U end from RNA. A targeted inhibition or suppression of the Nendo U would support the natural immune
answer to fight SARS-CoV-2 and similar viruses.
The Focal adhesion complex is of special interest for the development of anti cancer drugs. We are working to solve structures of so called stapled peptides which are a new class of drugs. Here we want to discover the structural binding behavior in the reaction coordinate.