Epigenetic crosstalk
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP309472
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资源简介：
We report a direct interaction between RNA epigenome and DNA epigenome. We demonstrate that m6A methyltransferase METTL3 regulates DNA methylation levels co-transcriptionally. We observed a genome-wide correlation between m6A / METTL3 and occupancy by the DNA demethylase TET1, and m6A reader physically interacts and recruits TET1 to m6A-associated chromatin regions. Our results demonstrates an original but unheeded feed-back regulatory mechanism from RNA epigenome to DNA epigenome and detect a new aspect of epigenetic crosstalk to regulate gene expression. Overall design: Examination of m6A methylation and DNA methylation levels
创建时间：
2022-09-22
