Danish National Birth Cohort

Exposures in the period from conception to early childhood - including fetal growth, cell division, and organ functioning - may have long-lasting impact on health and disease susceptibility. To investigate these issues the Danish National Birth Cohort (Better health in generations) was established. A large cohort of pregnant women with long-term follow-up of the offspring was the obvious choice because many of the exposures of interest cannot be reconstructed with suffcient validity back in time. The study needed to be large, and the aim was to recruit 100,000 women early in pregnancy, and to continue follow-up for decades. Exposure information was collected by computer-assisted telephone interviews with the women twice during pregnancy and when their children were six and 18 months old. Participants were also asked to fill in a self-administered food frequency questionnaire in mid-pregnancy. Furthermore, a biological bank has been set up with blood taken from the mother twice during pregnancy and blood from theumbilical cord taken shortly after birth.

从受孕至幼儿早期期间的暴露，包括胎儿生长、细胞分裂和器官功能，可能对健康和疾病易感性产生持久影响。为探究这些问题，丹麦国家出生队列（代际健康改善）得以建立。鉴于许多感兴趣的暴露无法以充分的有效性回溯重建，一支包含大量孕产妇且对其后代进行长期跟踪的大型队列无疑是明智之选。研究规模庞大，旨在在孕早期招募10万名妇女，并持续数十年进行跟踪。通过计算机辅助电话访谈，在孕期的两次以及孩子六个月和18个月大时，收集了暴露信息。此外，参与者还被要求在孕中期填写一份自填式食物频率问卷。此外，还建立了一个生物银行，收集了孕产妇在孕期的两次血液样本以及出生后不久的脐带血样本。