Human lupus and normal CD4 T cells response to anti-CD3 treatment
收藏官方服务：
资源简介：
Human lupus and normal CD4 T cells response to anti-CD3 treatment
应用场景：
创建时间：
2010-06-09
相关数据集
BET bromodomain inhibition suppresses TH17-mediated pathology. Mus musculus
IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation an
NIAID Data Ecosystem50
Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein
Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affin
NIAID Data Ecosystem40
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation o
NIAID Data Ecosystem20
Selective JAK1 inhibitors and the therapeutic applications thereof: a patent review (2016–2023)
The family of Janus kinases (JAKs) consists of four intracellular non-receptor tyrosine kinases: JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2). Among these four subtypes, JAK1 is the only isoform tha
Taylor & Francis Group2025-02-01 更新40
REV-ERBa regulates TH17 cell development and autoimmunity
RORγt is well recognized as the lineage defining transcription factor for TH17 cell development. However, the cell-intrinsic mechanisms that negatively regulate TH17 cell development and autoimmunity
NIAID Data Ecosystem40
