Transcriptional analysis of left-sided colitis, pancolitis and ulcerative colitis-associated dysplasia. Homo sapiens

This study characterizes the inflammatory processes in left-sided colitis, pancolitis, and UC-associated dysplasia at the transcriptional level in colonics biopsies in order to identify potential biomarkers and transcripts of importance for the carcinogenic behaviour of chronic inflammation Overall design: Colonic biopsies were obtained from forty-five patients with UC (20 left-sided colitis, 19 pancolitis, and 6 UC-associated dysplasia) and 15 controls. The Affymetrix GeneChip Human Genome U133 Plus 2.0 was used