Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor
收藏Protein Data Bank Japan2024-10-09 更新2026-03-21 收录
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Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor Descriptor: N-({3-[(5S)-5-tert-butyl-1-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzis othiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase Authors: Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. Deposit date: 2008-05-16 Release date: 2009-05-19 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2008-05-16
