An alternative pluripotent state confers interspecies chimaeric competency [WGBS]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
In this study, we show that by simple modulation of extrinsic signaling pathways, a new class of pluripotent stem cells, referred to as region selective epiblast stem cells (rsEpiSCs), could be efficiently derived from different stages of the early embryo. rsEpiSCs share features of primed pluripotency yet are distinct from EpiSCs in their molecular characteristics and ability to colonize post-implantation embryos. We performed whole-genome bisulfite sequencing (WGBS) experiments to compare the DNA methylation landscapes of conventional EpiSCs and rsEpiSCs.
提供机构：
University of California, San Diego (UCSD)
创建时间：
2022-02-20
