Supporting data for “DJ-1 Binding Compound Reduces Sensorimotor Functional Deficits by Suppressing Ferroptotic Neuronal Death after Experimental Intracerebral Haemorrhage”

This study investigated the roles of DJ-1 and DJ-1 oxidation in modulating neuronal ferroptosis after intracerebral haemorrhage (ICH) and highlighted the effects of DJ-1 binding compound on reducing neurofunctional deficits and the extent of ferroptotic neuronal death after ICH. The dataset contains supporting data for each result chapter. All <i>in vivo </i>data were derived from the experimental mouse model of intracerebral haemorrhage induced by intra-striatal collagenase injection. All <i>in vitro </i>data were obtained from the<i> </i>ICH<i> </i>neuronal model induced by hemin exposure. The data files include images of brain coronal slices, protein immunoblotting, Luxol fast blue staining, Nissl staining, immunofluorescence staining, and transmission electron microscopy. Their relevant quantification and data analysis are also included. Additionally, files include data analysis about RT-qPCR, behavioural tests, brain water content, haemoglobin assay, MTT assay, MDA assay, GPx4 activity assay and biothiol assays. All image files are in .jpg format, and all data analysis files are in .xlsx format.