Contrast of general data of various groups.

ObjectiveIt was to assess changes in structural parameters in early diabetic retinopathy (DR).Materials and methodologiesThis study is a retrospective analysis that included patients with early DR admitted to the Affiliated Third Hospital of Nantong University from January 2024 to December 2024. The participants were divided into the non-DR group (NDR group) and the non-proliferative DR group (NPDR group, which included mild, moderate, and severe subgroups) using swept-source optical coherence tomography angiography (SS-OCTA) technology. One-way analysis of variance (ANOVA) and the Kruskal-Wallis test were used to compare parameter differences among the groups.ResultsA total of 208 diabetic patients were included (55 in the NDR group, 153 in the NPDR group) and 51 healthy controls. The results showed that the FAZ area in the NPDR group was significantly larger than that in the control group (CG) (mean difference: +0.38 ± 0.10 mm2, 95% CI [0.25-0.51], P P PPConclusionSS-OCTA can effectively monitor changes in structural parameters and serves as a valuable tool for evaluating the progression of early DR.