Chemical reprogramming of human fibroblasts
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE123668
下载链接
链接失效反馈官方服务：
资源简介：
The compound (O4I3) showed a remarkable OCT4 induction, which at least in part, is due to the inhibition of H3K4-specific lysine demethylase (KDM5, also known as JARID1). Experiments demonstrated that KDM5A, serves as a reprogramming barrier via interference with the enrichment of H3K4Me3 at the OCT4 promoter. Thus, our results introduce a new class of KDM5 chemical inhibitors and provide further insight into the pluripotency-related properties of KDM5-family members. RNA was obtained from treated and non-treated human fibroblast and fibroblast-derived induced Pluripotent Stem Cells and treated with an episomal constrcuts of Oct4, Sox2, Klf4 and c-Myc in addition to O4I3
创建时间：
2019-02-13
