Characteristics of CHEK2 mutants found and clinical data

1, The bolded bases indicate the base change; T N M, TNM-classification, AJCC 2002 = UICC 2002, T, size or direct of the primary tumor; N, spread to regional lymph nodes; M, distant metastasis; 3, “F” followed by a number indicates that the patient was free of disease at that number of months of follow-up. “R” followed by a number indicates that the patient was alive at that number of months of follow-up but had suffered a relapse; ˆ, “A” followed by a number indicates that the patient was alive at that number of months of follow-up. “D” followed by a number indicates that the patient died at that number of months of follow-up; AI, Allelic imbalance; NI, Not informative; NA, Not available. “*” This patient subsequently relapsed with distant metastases at 64 months.