Characterization of the immune response to Mycobacterium marinum infection in zebrafish

Mycobacterium marinum infection in zebrafish (Danio rerio) has been widely used to study human tuberculosis because the bacteria causing these two diseases are close relatives. We studied the zebrafish immune response to M. marinum infection through a whole-genome level transcriptome analysis. As expected based on the literature, our results showed the induction of genes coding proteins associated to immune signaling, cell migration and acute phase response indicating that the immune response to M. marinum infection in zebrafish is similar than the response to tuberculosis causing Mycobacterium tuberculosis in humans. Overall design: Identification of the up- and downregulated genes in Mycobacterium marinum infection in zebrafish. 8 samples were analyzed, four biological replicates in each group.