E2F6 binds RRM2 gene promoter
收藏reactome.org2025-01-16 收录
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E2F6, presumably in complex with at least TFDP1 (DP-1) or TFDP2 (DP-2), binds the promoter of the E2F1 target gene RRM2. Binding of E2F6 to the RRM2 promoter is inhibited by CHEK1 mediated phosphorylation of E2F6 (Bertoli et al. 2013).
E2F6蛋白,推测与至少TFDP1(DP-1)或TFDP2(DP-2)形成复合物,结合E2F1靶基因RRM2的启动子。E2F6与RRM2启动子的结合受到CHEK1介导的E2F6磷酸化的抑制(Bertoli等,2013年)。
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