Expression data from docetaxel-resistant and cabazitaxel-resistant prostate cancer cell lines
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158494
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Docetaxel and cabazitaxel are the chemotherapy agents used in castration-resistant prostate cancer. However, most patients eventually develop resistance to these treatments. The aim of the study was to identify key molecular genes and networks associated with taxanes resistance in 2 models of docetaxel-resistant and cabazitaxel-resistant castration-resistant prostate cancer cell lines. DU-145 and PC-3 cells were converted to docetaxel-resistant cells (DU-145DR and PC-3DR, respectively) and to cabazitaxel-resistant cells (DU-145CZR and PC-3CZR, respectively). Whole-genome arrays were used to compare global gene expression between these 6 cell lines. Arrays were performed by triplicate for each cell line.
创建时间：
2020-11-24
