Dent1: Childhood Caries

[**Link to project pages of DENT1: Childhood Caries**](http://www.facebase.org/hgai/DENT1.html) dbGaP Study Accession: [phs000095.v3.p1](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000095.v3.p1) Principal Investigator: [Mary Marazita](https://www.dental.pitt.edu/person/mary-l-marazita), University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA Funding Sources: U01-DE018903, Dental Caries: Whole Genome Association and Gene x Environment Studies. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE014899, Factors contributing to oral health disparities in Appalachia. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R03-DE021425, Statistical Modeling and Genetic Epidemiology of Dental Caries in GWAS Analysis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE09551, Longitudinal study of fluoride, diet, caries, and fluorosis. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE12101, Fluoride and other factors in childhood and adolescent bone development. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA This study of dental caries comes from the [University of Pittsburgh’s Center for Craniofacial and Dental Genetics](https://www.dental.pitt.edu/center-craniofacial-and-dental-genetics) and focuses on childhood caries. This study is part of the Gene Environment Association Studies initiative ([GENEVA](https://www.genome.gov/27541319/gene-environment-association-studes-geneva/)), which was developed through the trans-NIH Genes, Environment, and Health Initiative (GEI). Information on how to obtain individual level data is available on dbGaP. Genotyping and quality control details are available on dbGaP and are briefly described in Shaffer et al. [Genome-wide Association Scan for Childhood Caries Implicates Novel Genes, J Dent Res 90(12):1457-1462, 2011](https://www.ncbi.nlm.nih.gov/pubmed/?term=enome-wide+Association+Scan+for+Childhood+Caries+Implicates+Novel+Genes). Dental caries is one of the most common diseases worldwide. In the US, the prevalence in adults is approximately 90% (Beltran-Aguilar et al., 2005), and in some high-risk populations, the prevalence is even higher. Treatment of dental caries consumes significant resources each year, and untreated caries lesions can lead to pain, tooth loss, and oral infection, or other co-morbidities. Cariogenesis is affected my numerous environmental, behavioral, and genetic factors, including dietary behaviors, bacterial flora, fluoride exposure, salivary factors, tooth morphology, etc. (Hunter, 1988; Anderson, 2002). This study includes analyses stratified by fluoride exposure, to address the role of genes and gene-by-fluoride interactions in the etiology of this disease. Click [here](/hgai/DENT1.html) to access the data and results for this dataset.