Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
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https://figshare.com/articles/dataset/Discovery_of_Second_Generation_Reversible_Covalent_DPP1_Inhibitors_Leading_to_an_Oxazepane_Amidoacetonitrile_Based_Clinical_Candidate_AZD7986_/4007337
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资源简介：
A novel
series of second generation DPP1 inhibitors free from aorta
binding liabilities found for earlier compound series was discovered.
This work culminated in the identification of compound 30 (AZD7986) as a highly potent, reversible, and selective clinical
candidate for COPD, with predicted human PK properties suitable for
once daily human dosing.
创建时间：
2016-10-21
