Chromatin occupancy profiling of AML transcription factors upon SWI/SNF inhibition [ChIP-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE217171
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To reveal the effects of SWI/SNF inhibition on genome-wide transcription factor occupancy in AML cells, we performed ChIP-seq in THP-1 cells, and compared the effects of BRM014 with DMSO vehicle control. We also examined the effects of SMARCA4 chromatin targeting via treatment with the PU.1 inhibitor DB2313. Analysis of genome-wide occupancy by ChIP-seq reveals that SWI/SNF inhibition impairs PU.1-directed enhancer programs in AML cells. Comparative chromatin occupancy profiling of transcription factors in AML cells treated with inhibitors of SWI/SNF or PU.1
创建时间：
2023-02-05
