Figure 6
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FIGURE 6 | Exosomes transfer miR-92b-3p to promote SCLC migration and chemoresistance. (A) TEM images of exosomes isolated from SCLC cells. (B) The sizeand quantitation of exosomes isolated from SCLC cells were examined by nanoparticle tracking analysis. (C) The levels of CD63 and TSG101 were detected bywestern blot. (D) Fluorescence microscopy images of SBC-3 cells after treatment with PKH26-labeled exosomes (green) stained with DAPI (blue). SBC-3 cells couldeffectively uptake the exosomes. (E) MiR-92b-3p and PTEN levels as detected by qRT-PCR. SCLC cells showed higher levels of miR-92b-3p and lower levels ofPTEN after they were incubated with exosomes. (F) SCLC cells displayed higher migration ability after incubation with exosomes. (G) DDP treatment inhibited tumorgrowth, whereas this inhibition was reversed after combination therapy with exosomes. Compared with SBC-3 NC group, *P < 0.05, **P < 0.01, and ***P < 0.001.All experiments were performed independently three times. SCLC, small cell lung cancer and TEM, transmission electron microscopy.
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创建时间：
2022-10-11
