Enhancement of glutamate uptake as novel antiseizure approach: Preclinical proof of concept – Research Data

<p><span style="color:black">The uploaded directory contains dataset for the article “</span><strong style="color:black">Enhancement of glutamate uptake as novel antiseizure approach: Preclinical proof of concept</strong><span style="color:black">” by Krzysztof Kamiński, Katarzyna Socała, Michał Abram, Marcin Jakubiec, Katelyn L. Reeb, Rhea Temmermand, Mirosław Zagaja, Maciej Maj, Magdalena Kolasa, Agata Faron-Górecka, Marta Andres-Mach, Aleksandra Szewczyk, Mustafa Q. Hameed, Andréia C. K. Fontana, Alexander Rotenberg, Rafał M. Kamiński published in </span><em style="color:black">Annals of Neurology</em><span style="color:black">, </span><strong style="color:black">2025</strong><span style="color:black">, </span><em style="color:black">97</em><span style="color:black">, 344–357 (</span><a href="https://doi.org/10.1002/ana.27124" target="_blank" style="color:black" rel="nofollow noopener noreferrer">https://doi.org/10.1002/ana.27124</a><span style="color:black">).</span></p><p><span style="color:black"> </span></p><p><strong style="color:black">The dataset includes</strong><span style="color:black">:</span></p><ol><li><em style="color:black">In vivo</em><span style="color:black"> antiseizure and safety data in animal models</span></li><li><strong style="color:black">(<em>R</em>)-AS-1</strong><span style="color:black"> glutamate uptake results mediated by EAAT2 in the presence or absence of the specific competitive EAAT2 inhibitor WAY 213613_SUMMARY</span></li><li><strong style="color:black">(<em>R</em>)-AS-1</strong><span style="color:black"> glutamate uptake results mediated by EAAT2 in the presence or absence of the specific competitive EAAT2 inhibitor WAY 213613_RAW DATA</span></li><li><span style="color:black">Effect of </span><strong style="color:black">(<em>R</em>)-AS-1</strong><span style="color:black"> on GLT-1/EAAT2 expression - </span><em style="color:black">in vitro</em><span style="color:black"> confocal microscopy and Western blotting results</span></li><li><span style="color:black">Effect of </span><strong style="color:black">(<em>R</em>)-AS-1</strong><span style="color:black"> on GLT-1/EAAT2 expression in neuron-glia cultures - Western Blotting results_RAW DATA</span></li></ol>