Using High-Throughput Technology to Establish an Auxiliary Detection Platform for Attention Deficit Hyperactivity Disorder for Child and Adolescent in Taiwan

As a clinically heterogeneous developmental syndrome, symptom or phenotype of ADHD may be caused by variations of copy number or genetic polymorphism in multiple locus. Numerous genome-wide association studies have shown strong evidence in genetic susceptibilities for ADHD, but most of them were examined on Caucasian population. To measure the distribution of persistent ADHD considering variants in Taiwanese individuals, we selected 6 variant number of tandem repeat polymorphisms (VNTRs) and 49 single nucleotide polymorphisms (SNPs) in a case-control study (200 cases and 1,000 healthy people). This study provides an obvious evidence of racial/ethnic differences which may alter the disease-related genetic patterns, and these targets are expected for further developing a polygenic risk score (PRS) of ADHD in practical clinical application.