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Gene expression profiles of Dclk1+ and Dclk1- PDAC cells

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE139167
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Doublecortin-like kinase 1 (Dclk1) is known as a cancer stem cell marker of pancreatic ductal adenocarcinoma (PDAC). But the functional evidence to define the stem cell activity of these cells within tumors has not been explored. We compared the gene expression profiles of Dclk1-positive and -negative PDACs cells. To determine the molecular characteristics of Dclk1+ PDAC cells, we performed microarray analysis on FACS-sorted Dclk1+ and Dclk1- PDAC cells obtained from Dclk1CreERT2-IRES-EGFP/+; Pdx1-Flp; KrasFSF-G12D/+; Trp53frt/frt (DKPF) mice.
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2021-01-19
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