METTL5, an 18S rRNA-specific m6A methyltransferase, regulates the Integrated Stress Response [eCLIP]
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https://www.ncbi.nlm.nih.gov/sra/SRP223540
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资源简介：
RNA N6-methyladenosine (m6A) modification is present in different RNA molecules, including protein-coding mRNAs and non-coding RNAs such as ribosomal RNAs (rRNAs).Here, we report that mammalian METTL5, a member of a highly conserved methyltransferase family, specifically methylates adenosine 1832 (A1832) in the 18S rRNA in vivo and in vitro. Overall design: We used eCLIP-seq to identify the binding targets of METTL5 in human 293T cells.
创建时间：
2020-09-21
