Insight into effects of COVID-19 on human heart and lung tissue at sub-cellular level

COVID-19 affects multiple vital organs and leads to drastic changes in tissue architecture not only in the lung but also in the heart. The understanding of these alterations is currently very limited and no high resolution 3D data is available. We propose to investigate damage in heart and lung tissue from patients having died with COVID-19 and who have undergone autopsy. This will be achieved by X-ray cryo-nano-holotomography. The aim of the proposal is to reveal the 3D changes occurring in tissue at cellular and sub-cellular levels, following terminal COVID-19 infection.