An Open Dataset for Multimodal Intervention in Older Adults

The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. In the present study, using a multimodal intervention comprised of cognitive training, Tai Chi and group counselling, we charted activity-driven, whole-brain functional-connectivity plasticity in healthy older adults. Specifically, we conducted a 6-week intervention trial with 45 community-dwelling older adults assigned to one of the 2 groups (multimodal intervention or control), 34 participants were included in the final analyses: 17 in the intervention group (9 men,mean age: 68.6 ± 5.7 years) and 17 in the control group (11 men, mean age: 71.7 ± 4.0 years).The image data was collected using a 3.0-Tesla Siemens Trio scanner (Erlangen, Germany) located at the Beijing MRI Center for Brain Research.