Tricomplex of Compound 3, KRAS G12D, and CypA

Tricomplex of Compound 3, KRAS G12D, and CypA Descriptor: (2R)-2-{(5S)-7-[(2R)-2-aminopropanoyl]-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl}-2-cyclopentyl-N-[(1M,8S,10S,14R,21M)-22-ethyl-4-hydroxy-21-{2-[(1R)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]acetamide (non-preferred name), CHLORIDE ION, Isoform 2B of GTPase KRas, ... Authors: Zhang, D, Bar Ziv, T, Knox, J.E, Yano, J.K. Deposit date: 2024-07-24 Release date: 2025-07-23 Last modified: 2025-08-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science, 389, 2025