Genome-wide epigenome mapping in human induced pluripotent cells in WT and KMT2CKO cells. [ATAC-Seq]

KMT2C is a histone methyltransferase that mono-methylates lysine four at enhancer regions. This study compares the open and closed chromatin region between WT and KMT2C KO cells and further evaluates their functional validation by applying the invitro hematopoietic differentiation protocol. Examination of open and closed chromatin region in WT and KMT2CKO hIPSCs cells.