In silico discovery of the blood cell interactome [microRNA]. In silico discovery of the blood cell interactome [microRNA]

The aim of the present study identify putative macromolecular interactions in human peripheral blood based on significant correlations at the transcriptional level. We found that significant transcript correlations within a giant matrix including also mRNAs from the same project reflect experimentally documented interactions Overall design: We performed transcriptional profiling of peripheral blood from Norwegian women (50–86 years, n=105) representing a cohort with varying bone mineral densities (BMDs) and free of primary diseases and medication known to affect the skeleton.