Macroautophagy is a highly conserved eukaryotic cellular pathway involving the engulfment of macromolecules, organelles, and invading microbes by a double-membrane compartment and subsequent lysosomal
(A) RT-PCR analysis of calpains 8 and 9 mRNA in the WT, Capn8+/−, Capn8−/−, Capn9+/−, and Capn9−/− gastric mucosa using primer pairs: calpain 8-5′/-3′ for calpain 8, calpain 9-5′/-3′ for calpain 9, an
IntroductionLC8 is a hub protein involved in many processes from tumor suppression and cell cycle regulation to neurotransmission and viral infection. Despite recent progress, prediction of binding si
Protein hotspot residues are key sites that mediate protein-protein interactions. Accurate identification of these residues is essential for understanding the mechanism from protein to function and fo
