PheWAS Tests of Association: Related Associations.

Related associations that met the criteria for PheWAS significance are given here, sorted by the number of PAGE site replications for a given phenotype-class. Related associations were defined as SNPs significantly associated in this PheWAS with phenotype-classes closely related to phenotypes among known associations. Significance was defined as a test of association with p<0.01 observed in two or more PAGE studies for the same SNP, phenotype-class, and race/ethnicity and consistent direction of effect when relevant. For each, the nearest gene(s), the SNP rs number, coded allele (CA) and frequency (CAF), associated phenotypes, phenotype-class, race/ethnicity, p-values, genetic effect/beta values (standard error; SE), sample sizes, substudies, number of substudies with results passing our p-value cutoff, the previously associated phenotype for that SNP, and references for the previously associated phenotypes are given.
1Coded Allele.
2Coded allele frequency.
3Associated phenotypes for individual results.
4Phenotype-class.
5Race/ethnicity for association, abbreviations: African American (AA), European American (EA), Mexican American/Hispanic (H).
6P-Values of results that passed p = 0.01 threshold in order of the associated phenotypes.
7Beta and standard error in order of the associated phenotypes.
8Sample size in order of the associated phenotypes.
9Studies with the significant result, in order of the associated phenotypes.
10Total number of studies with at least one result passing p-value threshold for specific phenotype-class and SNP.
11Previously reported associated phenotypes for SNP.
12Pubmed ID's for previously associated phenotypes.