Mapping the Landscape of a Eukaryotic Degronome

Alliance of Genome Resources2026-08-01 收录

蛋白质降解

降解组学

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https://www.yeastgenome.org/dataset/GSE72529 数据链接链接失效反馈

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Maintenance of cellular protein homeostasis requires controlled temporal and spatial protein degradation as well as the continuous removal of damaged proteins

Destabilisation and degradation of AXN in the 'destruction complex'

蛋白质降解

泛素-蛋白酶体系统

Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.

reactome.org90

Data_Sheet_3_Profiling of Protein Degraders in Cultures of Human Gut Microbiota.docx

结肠微生物群

蛋白质降解

Unabsorbed proteins reach the colon and are fermented by the microbiota, yielding a variety of harmful metabolites. In the present study, a 16S rRNA gene survey identified the bacterial taxa flourishi

NIAID Data Ecosystem40

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

蛋白质降解

靶向药物设计

Immunomodulatory imide drugs (IMiDs), including thalidomide, lenalidomide, and pomalidomide, can be used to induce degradation of a protein of interest that is fused to a short degron motif, which oft

NIAID Data Ecosystem20

Turnover of Amyloid Precursor Protein Family Members Determines Their Nuclear Signaling Capability

淀粉样前体蛋白

蛋白质降解

The amyloid precursor protein (APP) as well as its homologues, APP-like protein 1 and 2 (APLP1 and APLP2), are cleaved by α-, β-, and γ-secretases, resulting in the release of their intracellular doma

NIAID Data Ecosystem50

DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase

细胞周期调控

蛋白质降解

In eukaryotes, bulk histone expression occurs in the S phase of the cell cycle. This highly conserved system is crucial for genomic stability and proper gene expression. In metazoans, Stem-loop bindin

Taylor & Francis Group2016-08-09 更新20

Mapping the Landscape of a Eukaryotic Degronome

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