Pluripotent cells of the mammalian embryo undergo extensive chromatin rewiring to prepare for lineage commitment after implantation. Repressive H3K27me3, deposited by Polycomb Repressive Complex 2 (PR
Although Tead4 is well-known to be critical for blastocyst development and trophoblast lineage differentiation, the higher-order chromatin organization around this gene remains poorly understood. We a
Additional file 3: Fig. S3 A. Ectodermal dGRNs of Sp and Lv redrawn to reflect timing of first expression. Earliest time points are at the top and normalized hours post-fertilization are indicated on
