Genomewide mapping of Trim33 binding in Th17 cells. Genomewide mapping of Trim33 binding in Th17 cells

We report the genome-wide binding of Trim33 in Th17 cells. We found that more than 90% of Trim33 binding regions was located in non-conding sequence, and therefore reflect the role of Trim33 as a trancriptional co-factor. Trim33 was found to accumulate on cis-regulatory regions of genes that regulate the function of Th17 cells such as Il17a, Ccr6 and Il10. This study provides a basis for the comprehensive understanding of Trim33-mediated regulation of Th17 cells. Overall design: Examination of Trim33 binding in Th17 cells.