The Role of LINC01235 in Regulating Chromatin Accessibility
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271540
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资源简介：
LINC01235 plays a crucial role in HER2-positive breast cancer by regulating global histone modifications (H3K27ac, H3K9ac, H3K36me3) and promoting H2A.Z expression in its regulatory regions. It enhances the accessibility of DNA licensing factors at their promoter regions, leading to increased DNA replication and chromosomal instability. These mechanisms contribute to clonal expansion and resistance to anti-HER2 therapies, highlighting LINC01235 as a potential therapeutic target. ATAC-Seq was performed in ASO-NC and ASO-1235 HCC1954 cells .
创建时间：
2025-07-09
