scRNA and ATAC seq using mouse gastric epithelial cells

Gastric epithelium is maintained by long-lived stem cells. Gastric stem cells are supported by various stem cell niche factors, including R-spondin 3. R-spondin 3 binds to Lgr4 receptor and promotes stem cell function. Here, we use mice that overexpress R-spondin 3 and/or lack Lgr4 in the stomach, and analyze the transcriptomic and epigenetic status in whole epithelial cells in these mice at a single cell level. This analysis would be useful for understanding stem cell biology and pathogenesis in the stomach.