P6C transforms to 2AMAS

The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. (S)-1-piperideine-6-carboxylate (P6C), an intermediate of the pipecolate pathway, is in equilibrium with alpha-aminoadipate delta-semialdehyde (2AMAS), which connects the two degradative pathways. How peroxisomal P6C transports to mitochondrial 2AMAS is unknown (Hallen et al. 2013).苏氨酸途径是颅外组织中赖氨酸降解的主要途径，而哌嗪酸途径则在成年大脑中占主导地位。哌嗪酸途径的中间产物（S）-1-哌啶基-6-羧酸（P6C）与α-氨基戊二酸δ-半醛（2AMAS）处于平衡状态，该平衡连接了两种降解途径。至于过氧化物酶体中的P6C如何运输至线粒体中的2AMAS，目前尚无定论（Hallen等，2013年）。