Crystal Structure of TYK2 with novel pyrrolidinone inhibitor
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Crystal Structure of TYK2 with novel pyrrolidinone inhibitor Descriptor: 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 Authors: Skene, R.J, Hoffman, I.D. Deposit date: 2019-05-07 Release date: 2020-02-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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2019-05-07
