Jackson Heart Study Allelic Spectrum Sequencing Discovery

This sub-study phs000498 JHS Allelic Spectrum Seq contains genotype derived from sequence data and selected phenotype of subjects available from the phs000498 study. Summary level phenotypes for the NHLBI JHS Cohort study participants can be viewed at the top-level study page phs000286 JHS Cohort. Individual level phenotype data and molecular data for all JHS Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI JHS Cohort phs000286 study. Cardiovascular disease (CVD) is the leading cause of death in the US, affecting 64 million Americans and costing over 368 billion dollars annually. To elucidate causes of CVD, NIH established the Framingham Heart Study (FHS) in 1948. In 1971, 5000 adult children and spouses of original FHS participants... (for more see dbGaP study page.)