Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome
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Histone deacetylases (HDACs) 1 and 2 are Class I HDACs that are members of several transcriptional regulatory complexes including coREST, MIER, NuRD, and SIN3. The interaction of each HDAC within the complex is undefined. Our studies utilize Affinity Purification and Crosslinking Mass Spectrometry to define HDAC1 and 2 interactions. We determined the structures of NuRD, SIN3A, and coREST by integrative structural modeling.
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Zenodo创建时间：
2024-05-06
