The juxtaposition of Taurine in Bronchopulmonary Dysplasia

Conclusion: Hyperoxia exposure causes endoplasmic reticulum stress, increases taurine transporter degradation, and leads to taurine depletion in the neonatal lungs with subsequent metabolic dysregulation, resulting in poor alveolar formation of the neonatal lungs. We provide evidence of the never-being-reported protective role of taurine in neonatal lung development. The fact that taurine attenuates the severity of bronchopulmonary dysplasia by reducing hyperoxia-induced endoplasmic reticulum stress and mitochondrial dysfunction indicates its therapeutic potential for treating bronchopulmonary dysplasia.结论：高氧暴露可诱导内质网应激（endoplasmic reticulum stress），促进牛磺酸转运体（taurine transporter）降解，进而造成新生肺组织牛磺酸耗竭并引发后续代谢紊乱，最终导致新生肺肺泡发育不良。本研究提供了牛磺酸在新生肺发育中具有此前尚未见报道的保护作用的实验依据。牛磺酸可通过减轻高氧诱导的内质网应激与线粒体功能异常，缓解支气管肺发育不良（bronchopulmonary dysplasia）的病情严重程度，这一结果表明其具备治疗支气管肺发育不良的潜在临床价值。