ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3

In neutrophils, an unknown lipoxygenase may mediate hydrogen abstraction from 17(S)-hydroperoxy-docosapentaenoic acid (17(S)-Hp-DPAn-3) to form 16(S),17(S)-epoxy-docosapentaenoic acid (16(S),17(S)-epoxy-DPAn-3) (Dalli et al. 2013). If, as assumed, DPA metabolism follows the same path as DHA metabolism, the lipoxygenase could be the dual-functional 5-lipoxygenase (ALOX5). The formation of this epoxy intermediate is supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017).

在中性粒细胞中，一种未知的脂氧合酶可能催化17(S)-氢过氧二十碳五烯酸（17(S)-Hp-DPAn-3）的氢提取作用，从而形成16(S),17(S)-环氧二十碳五烯酸（16(S),17(S)-epoxy-DPAn-3）（Dalli等，2013年）。假设DPA的代谢途径与DHA的代谢途径相同，则该脂氧合酶可能是具有双重功能的5-脂氧合酶（ALOX5）。这一环氧中间体的形成得到了化学合成实验的支持（Aursnes等，2014年；Primdahl等，2017年）。