Heteroresistance among Pseudomonas aeruginosa in Cystic Fibrosis Patients

Pseudomonas aeruginosa in respiratory specimens from Cystic Fibrosis patients contains subpopulations of variable sensitivity to given antibiotics. This heteroresistance is not fully eludicated by standard microbiological techniques for clinical workup. Whole genome sequencing and machine learning successfully identified at least one predictor of resistance for all antibiotics in the vast majority of isolates from this sample.