A microRNA cluster in the DLK1-DIO3 imprinted region on chromosome 14q32.2 in hepatoblastoma

Using array-based expression analysis on formalin-fixed paraffin-embedded tissues, we aimed to identify miRNA signatures that can discriminate between lung metastatic tumors, primary tumors (fetal and embryonal subtypes) and nontumorous surrounding livers. A large cluster of microRNAs and snoRNAs located within the 14q32.2 DLK1-DIO3 region showed a strikingly upregulated expression pattern in HB tumors, especially metastatic tumors, compared to normal liver tissues. Here we examined microRNAs and snoRNAs profiles related to different type of hepatoblastoma tumor cells, using array-based expression analysis.