The role of SMAD7 on epigenetic regulation of TGF-β targets in the metastasis of ovarian cancer

Targeting TGF-β signaling and its downstream effectors, such as SMAD7, may offer promising therapeutic strategies for reversing epigenetic alterations and inhibiting metastatic progression in ovarian cancer. TGF-β signaling, a key regulator of EMT, may directly influence DNA methylation in the E-cadherin promoter. SMAD7 was overexpressed to investigate if sustained activation of TGF-β signaling contributes to DNA methylation of the E-cadherin promoter in ovarian cancer in a mesenchymal ovarian cancer cell