CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE155688
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资源简介：
We report that loss of CCM3/PDCD10 in fibroblasts induces FAK/Src-paxillin signalling driving actomyosin-dependent mechanotransduction leading to YAP/TAZ signalling. In vivo, loss of CCM3 in fibroblasts drives excessive tissue remodelling leading to the dissemination of breast cancer cells to distant organs. Examination of the varying RNA levels in control human vulval cancer-associated fibroblasts versus CCM3-depleted cells
创建时间：
2021-07-26
